Systematic Identification of H274Y Compensatory Mutations in Influenza A Virus Neuraminidase by High-Throughput Screening

Compensatory mutations contribute to the appearance of the oseltamivir resistance substitution H274Y in the neuraminidase (NA) gene of H1N1 influenza viruses. Here, we describe a high-throughput screening method utilizing error-prone PCR and next-generation sequencing to comprehensively screen NA ge...

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Bibliographic Details
Main Authors: Wu, Nicholas C., Young, Arthur P., Dandekar, Sugandha, Wijersuriya, Hemani, Al-Mawsawi, Laith Q., Wu, Ting-Ting, Sun, Ren
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554097/
https://ncbi.nlm.nih.gov/pubmed/23152521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01658-12
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