β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus USA300 Is Increased by Inactivation of the ClpXP Protease

Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a f...

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Main Authors: Bæk, Kristoffer T., Gründling, Angelika, Mogensen, René G., Thøgersen, Louise, Petersen, Andreas, Paulander, Wilhelm, Frees, Dorte
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136064/
https://ncbi.nlm.nih.gov/pubmed/24867990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02802-14
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