SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

Sterile alpha motif and histidine-aspartic domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase recently recognized as an antiviral factor that acts by depleting dNTP availability for viral reverse transcriptase (RT). SAMHD1 restriction is counteracted by...

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Detalhes bibliográficos
Main Authors: Ballana, Ester, Badia, Roger, Terradas, Gerard, Torres-Torronteras, Javier, Ruiz, Alba, Pauls, Eduardo, Riveira-Muñoz, Eva, Clotet, Bonaventura, Martí, Ramon, Esté, José A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136047/
https://ncbi.nlm.nih.gov/pubmed/24913159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03145-14
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