Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

OBJECTIVES: Sterile α motif and histidine–aspartate domain-containing protein 1 (SAMHD1) has been shown to restrict retroviruses and DNA viruses by decreasing the pool of intracellular deoxynucleotides. In turn, SAMHD1 is controlled by cyclin-dependent kinases (CDK) that regulate the cell cycle and...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Badia, Roger, Angulo, Guillem, Riveira-Muñoz, Eva, Pujantell, Maria, Puig, Teresa, Ramirez, Cristina, Torres-Torronteras, Javier, Martí, Ramón, Pauls, Eduardo, Clotet, Bonaventura, Ballana, Ester, Esté, José A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710216/
https://ncbi.nlm.nih.gov/pubmed/26542306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv363
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