Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy

Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase involved in the regulation of the intracellular dNTP pool, linked to viral restriction, cancer development and autoimmune disorders. SAMHD1 function is regulated by phosphorylation thro...

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發表在:Cancers (Basel)
Main Authors: Castellví, Marc, Felip, Eudald, Ezeonwumelu, Ifeanyi Jude, Badia, Roger, Garcia-Vidal, Edurne, Pujantell, Maria, Gutiérrez-Chamorro, Lucía, Teruel, Iris, Martínez-Cardús, Anna, Clotet, Bonaventura, Riveira-Muñoz, Eva, Margelí, Mireia, Ballana, Ester
格式: Artigo
語言:Inglês
出版: MDPI 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140116/
https://ncbi.nlm.nih.gov/pubmed/32197329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030713
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