Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy

Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase involved in the regulation of the intracellular dNTP pool, linked to viral restriction, cancer development and autoimmune disorders. SAMHD1 function is regulated by phosphorylation thro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Castellví, Marc, Felip, Eudald, Ezeonwumelu, Ifeanyi Jude, Badia, Roger, Garcia-Vidal, Edurne, Pujantell, Maria, Gutiérrez-Chamorro, Lucía, Teruel, Iris, Martínez-Cardús, Anna, Clotet, Bonaventura, Riveira-Muñoz, Eva, Margelí, Mireia, Ballana, Ester
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140116/
https://ncbi.nlm.nih.gov/pubmed/32197329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030713
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