Reclaiming the Efficacy of β-Lactam–β-Lactamase Inhibitor Combinations: Avibactam Restores the Susceptibility of CMY-2-Producing Escherichia coli to Ceftazidime

CMY-2 is a plasmid-encoded Ambler class C cephalosporinase that is widely disseminated in Enterobacteriaceae and is responsible for expanded-spectrum cephalosporin resistance. As a result of resistance to both ceftazidime and β-lactamase inhibitors in strains carrying bla(CMY), novel β-lactam–β-lact...

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Main Authors: Papp-Wallace, Krisztina M., Winkler, Marisa L., Gatta, Julian A., Taracila, Magdalena A., Chilakala, Sujatha, Xu, Yan, Johnson, J. Kristie, Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136032/
https://ncbi.nlm.nih.gov/pubmed/24820081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02625-14
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