Antiherpesvirus Activities of Two Novel 4′-Thiothymidine Derivatives, KAY-2-41 and KAH-39-149, Are Dependent on Viral and Cellular Thymidine Kinases

The emergence of drug-resistant herpesviruses represents a significant problem in clinical practice, primarily in immunocompromised patients. Furthermore, effective antiviral therapies against gammaherpesvirus-associated diseases are lacking. Here, we present two thiothymidine derivatives, KAY-2-41...

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Autori principali: Coen, Natacha, Duraffour, Sophie, Haraguchi, Kazuhiro, Balzarini, Jan, van den Oord, Joost J., Snoeck, Robert, Andrei, Graciela
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136010/
https://ncbi.nlm.nih.gov/pubmed/24820089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02825-14
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