Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum

Artemisinin (ART)-based combination therapy (ACT) is used as the first-line treatment of uncomplicated falciparum malaria worldwide. However, despite high potency and rapid action, there is a high rate of recrudescence associated with ART monotherapy or ACT long before the recent emergence of ART re...

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Bibliographic Details
Main Authors: Chen, Nanhua, LaCrue, Alexis N., Teuscher, Franka, Waters, Norman C., Gatton, Michelle L., Kyle, Dennis E., Cheng, Qin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135995/
https://ncbi.nlm.nih.gov/pubmed/24913167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02647-14
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