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Human Immunodeficiency Virus Reverse Transcriptase Displays Dramatically Higher Fidelity under Physiological Magnesium Conditions In Vitro

The fidelity of human immunodeficiency virus (HIV) reverse transcriptase (RT) has been a subject of intensive investigation. The mutation frequencies for the purified enzyme in vitro vary widely but are typically in the 10(−4) range (per nucleotide addition), making the enzyme severalfold less accur...

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Bibliografische gegevens
Hoofdauteurs: Achuthan, Vasudevan, Keith, Brian J., Connolly, Bernard A., DeStefano, Jeffrey J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135932/
https://ncbi.nlm.nih.gov/pubmed/24850729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00752-14
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