Single-Domain Antibodies Targeting Neuraminidase Protect against an H5N1 Influenza Virus Challenge

Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral potential. Two of them inhibited the NA activity and in vitro replication of clad...

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Autores principales: Cardoso, Francisco Miguel, Ibañez, Lorena Itatí, Van den Hoecke, Silvie, De Baets, Sarah, Smet, Anouk, Roose, Kenny, Schepens, Bert, Descamps, Francis J., Fiers, Walter, Muyldermans, Serge, Depicker, Ann, Saelens, Xavier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135927/
https://ncbi.nlm.nih.gov/pubmed/24829341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03178-13
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