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Sterilizing Activity of Thioridazine in Combination with the First-Line Regimen against Acute Murine Tuberculosis

We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of h...

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Detalhes bibliográficos
Main Authors: Dutta, Noton K., Pinn, Michael L., Karakousis, Petros C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135856/
https://ncbi.nlm.nih.gov/pubmed/24936590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03408-14
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