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Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice

Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given i...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dutta, Noton K., Pinn, Michael L., Karakousis, Petros C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527622/
https://ncbi.nlm.nih.gov/pubmed/28559262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00652-17
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