Safety and Pharmacokinetics of XOMA 3AB, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin A

Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin...

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Main Authors: Nayak, S. U., Griffiss, J. M., McKenzie, R., Fuchs, E. J., Jurao, R. A., An, A. T., Ahene, A., Tomic, M., Hendrix, C. W., Zenilman, J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135817/
https://ncbi.nlm.nih.gov/pubmed/24913160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02830-14
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