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The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

Phosphorylation of Thr161, a residue conserved in all members of the cdc2 family, has been reported to be absolutely required for the catalytic activity of cdc2, the major regulator of eukaryotic cell cycle. In the present work, we have purified from starfish oocytes a kinase that specifically activ...

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Udgivet i:EMBO J
Principais autores: Fesquet, D, Labbé, J C, Derancourt, J, Capony, J P, Galas, S, Girard, F, Lorca, T, Shuttleworth, J, Dorée, M, Cavadore, J C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413577/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8344251/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05980.x
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