IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex

IκB kinase ε (IKKε, IKBKE) is a key regulator of innate immunity and a breast cancer oncogene, amplified in ~30% of breast cancers, that promotes malignant transformation through NF-κB activation. Here we show that IKKε is modified and regulated by K63-linked polyubiquitination at Lysine 30 and Lysi...

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Bibliographic Details
Main Authors: Zhou, Alicia Y., Shen, Rhine R., Kim, Eejung, Lock, Ying J., Xu, Ming, Chen, Zhijian J., Hahn, William C.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135466/
https://ncbi.nlm.nih.gov/pubmed/23453969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.01.031
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