Targeting Poly (ADP-Ribose) Polymerase and the c-Myb-TopBP1-ATR-Chk1 Signaling Pathway in Castration-Resistant Prostate Cancer

Androgen deprivation is the standard systemic treatment for advanced prostate cancer (PCa), but most patients ultimately develop castration-resistance. We show here that MYB is transcriptionally activated by androgen deprivation or impairment of androgen receptor (AR) signaling. MYB gene silencing s...

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Hauptverfasser: Li, Likun, Chang, Wenjun, Yang, Guang, Ren, Chengzhen, Park, Sanghee, Karantanos, Theodoros, Karanika, Styliani, Wang, Jianxiang, Yin, Jianhua, Shah, Parantu K., Takahiro, Hirayama, Dobashi, Masato, Zhang, Wenling, Efstathiou, Eleni, Maity, Sankar N., Aparicio, Ana M., Tapia, Elsa M Li Ning, Troncoso, Patricia, Broom, Bradley, Xiao, Lianchun, Lee, Hyun-Sung, Lee, Ju-Seog, Corn, Paul G., Navone, Nora, Thompson, Timothy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135429/
https://ncbi.nlm.nih.gov/pubmed/24847116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005070
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