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Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests

There is substantial interest in the role of rare genetic variants in the etiology of complex human diseases. Several gene-based tests have been developed to simultaneously analyze multiple rare variants for association with phenotypic traits. The tests can largely be partitioned into two classes –...

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Detalhes bibliográficos
Main Authors: Zawistowski, Matthew, Reppell, Mark, Wegmann, Daniel, St Jean, Pamela L, Ehm, Margaret G, Nelson, Matthew R, Novembre, John, Zöllner, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135410/
https://ncbi.nlm.nih.gov/pubmed/24398795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.297
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