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Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
INTRODUCTION: Unwanted drug interactions with ionic currents in the heart can lead to an increased proarrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of auto...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135079/ https://ncbi.nlm.nih.gov/pubmed/23651875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2013.04.007 |
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