Prediction of Thorough QT study results using action potential simulations based on ion channel screens

INTRODUCTION: Detection of drug-induced pro-arrhythmic risk is a primary concern for pharmaceutical companies and regulators. Increased risk is linked to prolongation of the QT interval on the body surface ECG. Recent studies have shown that multiple ion channel interactions can be required to predi...

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Publicado en:J Pharmacol Toxicol Methods
Main Authors: Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266452/
https://ncbi.nlm.nih.gov/pubmed/25087753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2014.07.002
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