Caspase-8 modulates Dectin-1 and CR3 driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans(1)

Inflammasomes are central mediators of host defense to a wide range of microbial pathogens. The NLRP3 inflammasome plays a key role in triggering caspase-1 dependent IL-1β maturation and resistance to fungal dissemination in Candida albicans infection. β-glucans are major components of fungal cell w...

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Main Authors: Ganesan, Sandhya, Rathinam, Vijay A. K., Bossaller, Lukas, Army, Kelly, Kaiser, William J., Mocarski, Edward S., Dillon, Christopher P., Green, Douglas R., Mayadas, Tanya N., Levitz, Stuart M., Hise, Amy G., Silverman, Neal, Fitzgerald, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134963/
https://ncbi.nlm.nih.gov/pubmed/25063877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400276
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