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High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species
Podocyte number is significantly reduced in diabetic patients and animal models, but the mechanism remains unclear. In the present study, we found that high glucose induced apoptosis in control podocytes which express transient receptor potential canonical 6 (TRPC6) channels, but not in TRPC6 knockd...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134943/ https://ncbi.nlm.nih.gov/pubmed/23499875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.02.031 |
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