Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

RATIONALE: Individuals with naturally occurring loss-of-function PCSK9 mutations experience reduced blood low-density lipoprotein cholesterol (LDL-C) levels and protection against cardiovascular disease. OBJECTIVE: The goal of this study was to assess whether genome editing using a clustered regular...

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Autors principals: Ding, Qiurong, Strong, Alanna, Patel, Kevin M., Ng, Sze-Ling, Gosis, Bridget S., Regan, Stephanie N., Rader, Daniel J., Musunuru, Kiran
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134749/
https://ncbi.nlm.nih.gov/pubmed/24916110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.304351
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