Acute administration of a small molecule p75(NTR) ligand does not prevent hippocampal neuron loss nor development of spontaneous seizures after pilocarpine-induced status epilepticus

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are initially expressed in a precursor form (e.g., proBDNF) and cleaved to form mature BDNF (mBDNF). Following pilocarpine-induced status epilepticus (SE), increases in neurotrophins regulate a wide variety of cell signaling pathways i...

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Main Authors: Grabenstatter, H.L., Carlsen, J., Raol, Y.H., Yang, T., Hund, D., Del Angel, Y. Cruz, White, A.M., Gonzalez, M.I., Longo, F.M., Russek, S.J., Brooks-Kayal, A.R.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134742/
https://ncbi.nlm.nih.gov/pubmed/24801281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23402
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