A Therapeutic Trial of Decitabine and Vorinostat in Combination with Chemotherapy for Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL)

DNA hypermethylation and histone deacetylation are pathways of leukemia resistance. We investigated the tolerability and efficacy of decitabine and vorinostat plus chemotherapy in relapse/refractory acute lymphoblastic leukemia (ALL). Decitabine (15mg/m(2) iv) and vorinostat (230mg/m(2) PO div BID)...

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Main Authors: Burke, Michael J., Lamba, Jatinder K, Pounds, Stanley, Cao, Xueyuan, Ghodke-Puranaik, Yogita, Lindgren, Bruce R., Weigel, Brenda J., Verneris, Michael R., Miller, Jeffrey S.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134715/
https://ncbi.nlm.nih.gov/pubmed/24891274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23778
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