A Phase I Study of Vorinostat in Combination with Idarubicin in Relapsed or Refractory Leukaemia

Histone deacetylase inhibitors (HDACi) affect chromatin remodeling and modulate the expression of aberrantly silenced genes. HDACi have single-agent clinical activity in haematological malignancies and have synergistic anti-leukaemia activity when combined with anthracyclines in vitro. We conducted...

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Huvudupphovsmän: Kadia, Tapan M., Yang, Hui, Ferrajoli, Alessandra, Maddipotti, Sirisha, Schroeder, Claudia, Madden, Timothy L., Holleran, Julianne L., Egorin, Merrill J., Ravandi, Farhad, Thomas, Deborah A., Newsome, Willie, Sanchez-Gonzalez, Blanca, Zwiebel, James A., Espinoza-Delgado, Igor, Kantarjian, Hagop M., Garcia-Manero, Guillermo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124904/
https://ncbi.nlm.nih.gov/pubmed/20456355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08211.x
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