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Minocycline and Doxycycline, but not Tetracycline, Mitigate Liver and Kidney Injury after Hemorrhagic Shock/Resuscitation

BACKGROUND: Despite recovery of hemodynamics by fluid resuscitation after hemorrhage, development of the systemic inflammatory response and multiple organ dysfunction syndromes can nonetheless lead to death. Minocycline and doxycycline are tetracycline derivatives that are protective in models of hy...

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Autors principals: Kholmukhamedov, Andaleb, Czerny, Christoph, Hu, Jiangting, Schwartz, Justin, Zhong, Zhi, Lemasters, John J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134396/
https://ncbi.nlm.nih.gov/pubmed/24978888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000213
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