The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells.

Lysosomal acid phosphatase (LAP) is synthesized as a type I membrane glycoprotein and targeted to lysosomes via the plasma membrane. Its cytoplasmic tail harbours a tyrosine-containing signal for rapid internalization. Expression in Madine-Darby canine kidney cells results in direct sorting to the b...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Prill, V, Lehmann, L, von Figura, K, Peters, C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8491206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05866.x
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