Interference with PPARγ in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction

S-P467L mice expressing dominant negative Peroxisome Proliferator Activated Receptor-γ selectively in vascular smooth muscle, exhibit impaired vasodilation, augmented vasoconstriction, hypertension and tachycardia. We hypothesized that tachycardia in S-P467L mice is due to baroreflex dysfunction. S-...

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Autori principali: Borges, Giulianna R., Morgan, Donald A., Ketsawatsomkron, Pimonrat, Mickle, Aaron D., Thompson, Anthony P., Cassell, Martin D., Mohapatra, Durga P., Rahmouni, Kamal, Sigmund, Curt D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134389/
https://ncbi.nlm.nih.gov/pubmed/24914194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03553
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