D-cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and its Ligand FasL

D-type cyclins (D1, D2 and D3) are components of the mammalian core cell cycle machinery and function to drive cell proliferation. Here we report that D-cyclins perform a rate-limiting anti-apoptotic function in vivo. We found that acute shutdown of all three D-cyclins in bone marrow of adult mice r...

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Hauptverfasser: Choi, Yoon Jong, Saez, Borja, Anders, Lars, Hydbring, Per, Stefano, Joanna, Bacon, Nickolas A., Cook, Colleen, Kalaszczynska, Ilona, Signoretti, Sabina, Young, Richard A., Scadden, David T., Sicinski, Piotr
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134362/
https://ncbi.nlm.nih.gov/pubmed/25087893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.06.015
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