Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double Strand Breaks Regulate 53BP1 Nucleation and NHEJ-directed Repair

Although selective binding of 53BP1 to dimethylated histone H4 lysine 20 (H4K20me2) at DNA double strand breaks (DSBs) is a necessary and pivotal determinant of non-homologous end joining (NHEJ)-directed repair, the enzymes that generate H4K20me2 at DSBs were unclear. Here we determined that the PR-...

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Hauptverfasser: Tuzon, Creighton T., Spektor, Tanya, Kong, Xiaodong, Congdon, Lauren M., Wu, Shumin, Schotta, Gunnar, Yokomori, Kyoko, Rice, Judd C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134327/
https://ncbi.nlm.nih.gov/pubmed/25001286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.013
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