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Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double Strand Breaks Regulate 53BP1 Nucleation and NHEJ-directed Repair
Although selective binding of 53BP1 to dimethylated histone H4 lysine 20 (H4K20me2) at DNA double strand breaks (DSBs) is a necessary and pivotal determinant of non-homologous end joining (NHEJ)-directed repair, the enzymes that generate H4K20me2 at DSBs were unclear. Here we determined that the PR-...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134327/ https://ncbi.nlm.nih.gov/pubmed/25001286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.013 |
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