טוען...
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair. T...
שמור ב:
Main Authors: | , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
1993
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC413432/ https://ncbi.nlm.nih.gov/pubmed/8491199 |
תגים: |
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