Application of a Combination of a Knowledge-Based Algorithm and 2-Stage Screening to Hypothesis-Free Genomic Data on Irinotecan-Treated Patients for Identification of a Candidate Single Nucleotide Polymorphism Related to an Adverse Effect

Interindividual variation in a drug response among patients is known to cause serious problems in medicine. Genomic information has been proposed as the basis for “personalized” health care. The genome-wide association study (GWAS) is a powerful technique for examining single nucleotide polymorphism...

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Main Authors: Takahashi, Hiro, Sai, Kimie, Saito, Yoshiro, Kaniwa, Nahoko, Matsumura, Yasuhiro, Hamaguchi, Tetsuya, Shimada, Yasuhiro, Ohtsu, Atsushi, Yoshino, Takayuki, Doi, Toshihiko, Okuda, Haruhiro, Ichinohe, Risa, Takahashi, Anna, Doi, Ayano, Odaka, Yoko, Okuyama, Misuzu, Saijo, Nagahiro, Sawada, Jun-ichi, Sakamoto, Hiromi, Yoshida, Teruhiko
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134257/
https://ncbi.nlm.nih.gov/pubmed/25127363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105160
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