Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

Tumour-repopulating cells (TRCs) are a self-renewing, tumorigenic subpopulation of cancer cells critical in cancer progression. However, the underlying mechanisms of how TRCs maintain their self-renewing capability remain elusive. Here we show that relatively undifferentiated melanoma TRCs exhibit p...

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Autori principali: Tan, Youhua, Tajik, Arash, Chen, Junwei, Jia, Qiong, Chowdhury, Farhan, Wang, Lili, Chen, Junjian, Zhang, Shuang, Hong, Ying, Yi, Haiying, Wu, Douglas C., Zhang, Yuejin, Wei, Fuxiang, Poh, Yeh-Chuin, Seong, Jihye, Singh, Rishi, Lin, Li-Jung, Doğanay, Sultan, Li, Yong, Jia, Haibo, Ha, Taekjip, Wang, Yingxiao, Huang, Bo, Wang, Ning
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133791/
https://ncbi.nlm.nih.gov/pubmed/25099074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5619
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