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General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels

The pore-lining helix (PLH) bundles are central to the function of all ion channels, as their conformational rearrangements dictate channel gating. Here we explore all plausible oligomeric arrangements of the PLH bundles within homomeric ion channels by building models using generic restraints. In p...

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Autors principals: Dai, Jian, Zhou, Huan-Xiang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133698/
https://ncbi.nlm.nih.gov/pubmed/25105557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5641
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