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P53 inhibition exacerbates late-stage anthracycline cardiotoxicity

AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity. Children are particularly sensitive to DOX-induced heart failure. Here, the impact of p53 inhibition on acute vs. late-stage DOX cardiotoxicity was examined in a juvenile...

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Bibliografski detalji
Glavni autori: Zhu, Wuqiang, Zhang, Wenjun, Shou, Weinian, Field, Loren J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133592/
https://ncbi.nlm.nih.gov/pubmed/24812279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu118
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