The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major determinant of virulence. Elimination of SARS-CoV E prot...

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Main Authors: Jimenez-Guardeño, Jose M., Nieto-Torres, Jose L., DeDiego, Marta L., Regla-Nava, Jose A., Fernandez-Delgado, Raul, Castaño-Rodriguez, Carlos, Enjuanes, Luis
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133396/
https://ncbi.nlm.nih.gov/pubmed/25122212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004320
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