Evidence for the Role of Active Site Residues in the Hairpin Ribozyme from Molecular Simulations along the Reaction Path

[Image: see text] The hairpin ribozyme accelerates a phosphoryl transfer reaction without catalytic participation of divalent metal ions. Residues A38 and G8 have been implicated as playing roles in general acid and base catalysis, respectively. Here we explore the structure and dynamics of key acti...

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Hlavní autoři: Heldenbrand, Hugh, Janowski, Pawel A., Giambaşu, George, Giese, Timothy J., Wedekind, Joseph E., York, Darrin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132952/
https://ncbi.nlm.nih.gov/pubmed/24842535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja500180q
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