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Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering
[Image: see text] The epidermal growth factor receptor (EGFR) is aberrantly activated in various cancer cells and an important target for cancer treatment. Deep understanding of EGFR conformational changes between the active and inactive states is of pharmaceutical interest. Here we present a strate...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American
Chemical Society
2014
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132868/ https://ncbi.nlm.nih.gov/pubmed/25136273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct500162b |
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