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High-Throughput and Combinatorial Gene Expression on a Chip for Metabolism-Induced Toxicology Screening
Differential expression of various drug-metabolizing enzymes in the human liver may cause deviations of pharmacokinetic profiles, resulting in inter-individual variability of drug toxicity and/or efficacy. Here we present the “Transfected Enzyme and Metabolism Chip” (TeamChip), which predicts potent...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132844/ https://ncbi.nlm.nih.gov/pubmed/24799042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4739 |
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