High-Throughput and Combinatorial Gene Expression on a Chip for Metabolism-Induced Toxicology Screening

Differential expression of various drug-metabolizing enzymes in the human liver may cause deviations of pharmacokinetic profiles, resulting in inter-individual variability of drug toxicity and/or efficacy. Here we present the “Transfected Enzyme and Metabolism Chip” (TeamChip), which predicts potent...

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Bibliographische Detailangaben
Hauptverfasser: Kwon, Seok Joon, Lee, Dong Woo, Shah, Dhiral A., Ku, Bosung, Jeon, Sang Youl, Solanki, Kusum, Ryan, Jessica D., Clark, Douglas S., Dordick, Jonathan S., Lee, Moo-Yeal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132844/
https://ncbi.nlm.nih.gov/pubmed/24799042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4739
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