Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy

The cardiac troponin I (cTnI) R21C (cTnI-R21C) mutation has been linked to hypertrophic cardiomyopathy and renders cTnI incapable of phosphorylation by PKA in vivo. Echocardiographic imaging of homozygous knock-in mice expressing the cTnI-R21C mutation shows that they develop hypertrophy after 12 mo...

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Hauptverfasser: Dweck, David, Sanchez-Gonzalez, Marcos A., Chang, Audrey N., Dulce, Raul A., Badger, Crystal-Dawn, Koutnik, Andrew P., Ruiz, Edda L., Griffin, Brittany, Liang, Jingsheng, Kabbaj, Mohamed, Fincham, Frank D., Hare, Joshua M., Overton, J. Michael, Pinto, Jose R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132808/
https://ncbi.nlm.nih.gov/pubmed/24973218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561472
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