The Serotonin Transporter Undergoes Constitutive Internalization and Is Primarily Sorted to Late Endosomes and Lysosomal Degradation

The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. The molecular and cellular mechanisms controlling SERT levels in the membrane remain poorly understood. To study trafficking of the surface reside...

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Main Authors: Rahbek-Clemmensen, Troels, Bay, Tina, Eriksen, Jacob, Gether, Ulrik, Jørgensen, Trine Nygaard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132800/
https://ncbi.nlm.nih.gov/pubmed/24973209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495754
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