Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis

Desmoplastic malignancies such as cholangiocarcinoma (CCA) are characterized by a dense stroma containing an abundance of myofibroblasts termed cancer-associated fibroblasts (CAF). The CAF phenotype represents an “activated state” in which cells are primed for cell death triggered by BH3 mimetics. A...

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Main Authors: Rizvi, Sumera, Mertens, Joachim C., Bronk, Steven F., Hirsova, Petra, Dai, Haiming, Roberts, Lewis R., Kaufmann, Scott H., Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132787/
https://ncbi.nlm.nih.gov/pubmed/24973208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563064
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