Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner

DHX9 is an ATP-dependent DEXH box helicase with a multitude of cellular functions. Its ability to unwind both DNA and RNA, as well as aberrant, noncanonical polynucleotide structures, has implicated it in transcriptional and translational regulation, DNA replication and repair, and maintenance of ge...

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Detalhes bibliográficos
Main Authors: Lee, Teresa, Di Paola, Domenic, Malina, Abba, Mills, John R., Kreps, Amina, Grosse, Frank, Tang, Hengli, Zannis-Hadjopoulos, Maria, Larsson, Ola, Pelletier, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132785/
https://ncbi.nlm.nih.gov/pubmed/24990949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568535
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