Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner

DHX9 is an ATP-dependent DEXH box helicase with a multitude of cellular functions. Its ability to unwind both DNA and RNA, as well as aberrant, noncanonical polynucleotide structures, has implicated it in transcriptional and translational regulation, DNA replication and repair, and maintenance of ge...

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Main Authors: Lee, Teresa, Di Paola, Domenic, Malina, Abba, Mills, John R., Kreps, Amina, Grosse, Frank, Tang, Hengli, Zannis-Hadjopoulos, Maria, Larsson, Ola, Pelletier, Jerry
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132785/
https://ncbi.nlm.nih.gov/pubmed/24990949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568535
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