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A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
Loss-of-function mutations in the genes encoding PINK1 and Parkin (also known as PARK2) are the most common causes of recessive Parkinson's disease. Both together mediate the selective degradation of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathw...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Company of Biologists
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132391/ https://ncbi.nlm.nih.gov/pubmed/24928900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.147520 |
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