The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes

Nibrin plays an important role in the DNA damage response (DDR) and DNA repair. DDR is a crucial signaling pathway in apoptosis and senescence. To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and S3...

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Main Authors: Alster, Olga, Bielak-Zmijewska, Anna, Mosieniak, Grazyna, Moreno-Villanueva, Maria, Dudka-Ruszkowska, Wioleta, Wojtala, Aleksandra, Kusio-Kobiałka, Monika, Korwek, Zbigniew, Burkle, Alexander, Piwocka, Katarzyna, Siwicki, Jan K., Sikora, Ewa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132076/
https://ncbi.nlm.nih.gov/pubmed/25119968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104964
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