The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes

Nibrin plays an important role in the DNA damage response (DDR) and DNA repair. DDR is a crucial signaling pathway in apoptosis and senescence. To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and S3...

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Detalhes bibliográficos
Main Authors: Alster, Olga, Bielak-Zmijewska, Anna, Mosieniak, Grazyna, Moreno-Villanueva, Maria, Dudka-Ruszkowska, Wioleta, Wojtala, Aleksandra, Kusio-Kobiałka, Monika, Korwek, Zbigniew, Burkle, Alexander, Piwocka, Katarzyna, Siwicki, Jan K., Sikora, Ewa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132076/
https://ncbi.nlm.nih.gov/pubmed/25119968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104964
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