CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110)

CHK2 kinase is a key mediator in many cellular responses to genotoxic stresses including ionizing radiation and topoisomerase inhibitors. Upon ionizing radiation, CHK2 is activated by ATM kinase and regulates the S-phase and G1-S checkpoints, apoptosis, and DNA repair by phosphorylating downstream t...

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Main Authors: Choi, Hee-Hyun, Choi, Hyun-Kyung, Jung, Sung Yun, Hyle, Judith, Kim, Beom-Jun, Yoon, Keejung, Cho, Eun-Jung, Youn, Hong-Duk, Lahti, Jill M., Qin, Jun, Kim, Seong-Tae
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131284/
https://ncbi.nlm.nih.gov/pubmed/23178491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.535
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