Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

In addition to the tumor suppressor p53 protein, also termed p53α, the TP53 gene produces p53β and p53γ through alternative splicing of exons 9β and 9γ located within TP53 intron 9. Here we report that both TG003, a specific inhibitor of Cdc2-like kinases (Clk) that regulates the alternative splicin...

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Bibliographic Details
Main Authors:	Marcel, V, Fernandes, K, Terrier, O, Lane, D P, Bourdon, J-C
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2014
Subjects:	Original Paper
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4131182/ https://ncbi.nlm.nih.gov/pubmed/24926616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.73
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Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

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